PDRN (Polydeoxyribonucleotide)
PDRN (Polydeoxyribonucleotide) is a skin-rejuvenating ingredient derived from salmon DNA that is widely used in premium skincare for its ability to support skin renewal and boost radiance. Popular in Korean and UK beauty routines, it helps skin look smoother, firmer and more hydrated without irritation. It is considered gentle enough for most skin types and is often found in serums, masks and eye creams.
How it works in skincare
In cosmetics PDRN works by providing naturally occurring nucleotides that support the skin’s natural repair and regeneration processes. When applied topically it helps stimulate collagen and elastin production while improving skin barrier function and hydration levels, resulting in a plumper, more even-toned appearance. Its gentle profile makes it a favourite in soothing and anti-ageing formulations.
Key benefits
- Helps improve skin elasticity and firmness
- Enhances overall skin hydration and plumpness
- Supports a brighter, more even skin tone
- Soothes redness and irritation
- Promotes a smoother skin texture
- Helps reduce the appearance of fine lines
Best for
mature skin, dry skin, sensitive skin, dull skin, ageing skin
Where it comes from
PDRN is sourced from the DNA of wild salmon sperm, a natural marine-derived ingredient that is highly purified for cosmetic use.
Products with PDRN (Polydeoxyribonucleotide)
Not every product on UK Lips lists a full ingredient breakdown — so there may be many more formulas that contain PDRN (Polydeoxyribonucleotide) than we can show here. These are the comparisons where we’ve confirmed it in the listed ingredients.
- SkinCeuticals Phyto Corrective PDRN Serum (30ml) SkinCeuticals
- Medik8 Exo-PDRN Prismatic+ (30ml) Medik8