Gluconolactone (PHA)
Gluconolactone, often labelled as PHA, is a gentle next-generation acid that exfoliates, hydrates and protects the skin without the sting or irritation associated with stronger acids. Popular in UK skincare for its multi-tasking abilities, it is ideal for sensitive, dry or redness-prone skin and works beautifully alongside other active ingredients.
How it works in skincare
In cosmetics and skincare Gluconolactone functions as a polyhydroxy acid that gently breaks down the bonds between dead skin cells on the surface, promoting smoother texture and brighter tone. Its large molecular size prevents deep penetration, making it far less irritating than AHAs or BHAs, while its humectant properties draw moisture into the skin. It also acts as an antioxidant and chelating agent, helping to stabilise formulas and protect against environmental damage.
Key benefits
- Gentle surface exfoliation for smoother skin texture
- Boosts skin hydration and plumpness
- Strengthens the skin barrier
- Reduces the appearance of fine lines and dullness
- Calms redness and sensitivity
- Compatible with retinoids, vitamin C and niacinamide
Best for
sensitive skin, dry skin, mature skin, redness-prone skin, barrier-impaired skin
Where it comes from
Gluconolactone is naturally derived from the oxidation of glucose, which can be sourced from corn, rice or other plant starches.